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KMID : 0928320110110040177
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Korean Journal of Health Promotion and Disease Prevention
2011 Volume.11 No. 4 p.177 ~ p.183
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Influence of Stomach Cancer Risk Factors on the Development of Gastric Dysplasia
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Heo Jeong-Yun
Park Young-Jin
Han Seong-Ho
Park Joo-Sung
Bae Eun-Jin
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Abstract
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Background: Both atrophic gastritis and intestinal metaplasia may progress to gastric dysplasia. This study aimed to analyze the factors influencing progression of atrophic gastritis and intestinal metaplasia to dysplasia.
Methods: People diagnosed with atrophic gastritis and intestinal metaplasia for the first time received a follow- up endoscopy and were investigated for the cumulative incidence rate of gastric dysplasia by age, gender, smoking habit, alcohol intake, rice consumption and family history of stomach cancer.
Results: The cumulative incidence rate increased with age, consuming ≥3 bowls of rice per day and family history of stomach cancer. Multivariate analysis showed that the cumulative incidence rate of gastric dysplasia increased in subjects >61 years (RR=2.54, P=0.014), in those consuming ≥3 bowls of rice per day (RR=1.46, P=0.021) and in those with a family history of stomach cancer (RR=1.31, P=0.037).
Conclusions: More active management, such as intensive endoscopic follow-up examinations, lifestyle change and education regarding gastric dysplasia, are required in those older than 61 years, having a higher intake of grain or with a family history of stomach cancer.
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KEYWORD
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Atrophic gastritis, Metaplasia, Stomach neoplasm
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